產品屬性:
產品名稱 | Pimprinine |
規(guī)格 | 1mg、5mg |
貨號 | EY-01Y20462 |
Cas No.: 13640-26-1
別名: N/A
化學名: 3-(2-methyl-5-oxazolyl)-1H-indole
分子式: C12H10N2O
分子量: 198.2
溶解度: DMF: soluble,DMSO: soluble,Ethanol: soluble,Methanol: soluble
儲存條件: Store at -20°C
General tips:For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition:Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述:
Pimprinine is an alkaloid originally isolated from Streptomyces that has diverse biological activities, including anticonvulsant, antiplatelet, and antimicrobial properties. It inhibits deamination of serotonin by monoamine oxidase (MAO; IC50 = 48 μM). Pimprinine (80 mg/kg) increases the minimum and maximum electroshock seizure thresholds in mice. In a mouse model of tremorine-induced tremors, it increases the latency to tremor onset, as well as reduces the intensity and duration of tremors and the analgesic activity of tremorine when administered at a dose of 80 mg/kg. Pimprinine inhibits aggregation of rabbit platelets induced by arachidonic acid or collagen (IC50s = 3 and 25 μg/ml, respectively) and arachidonic acid-induced thromboxane A2 (TXA2) synthesis in rabbit platelets in vitro (IC50 = 6 μg/ml). It also inhibits the growth of M. tuberculosis, P. varioti, C. albicans, and S. lutea in vitro (MICs = 25, 1, 1.5, and 2.5 μg/ml, respectively).
特別提醒公司產品僅供科研使用