產(chǎn)品屬性:
產(chǎn)品名稱 | Rink Amide-MBHA Resin |
規(guī)格 | 5g、25g、100g |
貨號(hào) | EY-01Y18175 |
Cas No.: 431041-83-7
分子式: 100-200:mesh,1%DVB
分子量: 0.3~0.8mmol/g
溶解度:
儲(chǔ)存條件:
General tips:For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition:Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產(chǎn)品描述:
Rink Amide-MBHA resin is less acid sensitive than Rink Amide resin since the benzhydrylamine linker is joined to the support through an electron-withdrawing acetamido spacer. Usually the products are detached from the resin using 95%TFA in DCM and scavengers required by the substrate composition. In addition, Rink Amide-MBHA resin is also useful for peptide syntheses. Previous study has recently reported the syntheses of tri-, tetra- and pentapeptides via a solid phase synthesis methodology by using a Rink Amide MBHA resin[1].Rink Amide-MBHA resin: 4-(2',4'-Dimethoxypheyl-Fmoc-aminomethyl-phenoxy-acetamido- norleucyl-MBHA resin; Substitution: 0.4 - 0.8 mmole/g resin; Bead size 100- 200 mesh (polystyrene- 1% DVB)Structure:Appication: Using the Rink Amide MBHA resin and a Fmoc strategy giving C-terminal amide form peptides, substituted benzhydrylamine and benzylamine linkage agents useful for the solid phase peptide synthesis were evaluated for their relative lability toward trifluoroacetic acid. The two most reactive linkage agents studied were compared in the synthesis of two different peptide amides by the N α-9-fluorenylmethyloxycarbonyl protecting group strategy [2].
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