產(chǎn)品屬性：
產(chǎn)品名稱 | AWL-II-38.3 |
規(guī)格 | 5 mg、10 mg、25 mg、50 mg |
貨號(hào) | EY-01Y18070 |
Cas No.: 1135205-94-5
別名: N/A
化學(xué)名: N/A
分子式: C23H18F3N5O3
分子量: 469.42
溶解度: DMSO : 66.67 mg/mL (142.03 mM; Need ultrasonic)
儲(chǔ)存條件: Store at -20°C
General tips:For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition:Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產(chǎn)品描述：
AWL-II-38.3 is a potent ephrin-A receptor (EphA3) kinase inhibitor. AWL-II-38.3 does not exhibit significant cellular activity against Src-family kinases nor against b-raf[1][2][1][2].AWL-II-38.3 fits to LIMK2 and LIMK1 ATP-binding and substrate-binding pockets[2].[1]. Yongmun Choi, et al. Discovery and structural analysis of Eph receptor tyrosine kinase inhibitors. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4467-70. [2]. Efrat Mashiach-Farkash, et al. Computer-based identification of a novel LIMK1/2 inhibitor that synergizes with salirasib to destabilize the actin cytoskeleton. Oncotarget. 2012 Jun;3(6):629-39.
特別提醒公司產(chǎn)品僅供科研使用
