產(chǎn)品屬性：
產(chǎn)品名稱(chēng) | ZT-12-037-01 |
規(guī)格 | 1mg、5mg |
貨號(hào) | EY-01Y17359 |
Cas No.: 2328073-61-4
別名: N/A
化學(xué)名: N/A
分子式: C21H31N5O2
分子量: 385.5
溶解度: DMSO: 8.33 mg/mL (21.61 mM)
儲(chǔ)存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產(chǎn)品描述：
ZT-12-037-01 is a STK19-targeted inhibitor, has a high-affinity interaction with STK19 protein and inhibits oncogenic NRAS-driven melanocyte malignant transformation. ZT-12-037-01 is an ATP-competitive inhibitor, inhibiting phosphorylation of NRAS (major isoform of Ras family) with an IC50 of 24 nM[1].ZT-12-037-01 (3 μM; 14 days) significantly inhibits mutant NRAS-STK19-driven melanocyte colony formation and proliferation[1].ZT-12-037-01 (0-3 μM) has an inhibitory effects of ZT-12-037-01 on STK19WT and STK19D89N-activated NRAS phosphorylation in HPMs[1].Cell Proliferation Assay[1] Cell Line:CDK4 (R24C) melanocyte cells; hTERT melanocyte cells; p53DD melanocyte cellsZT-12-037-01 (injection subcutaneously; 25-50 mg/kg; once daily; 21 days) inhibits growth of SK-MEL-2 xenograft melanoma and the sections of tumors indicates induction of apoptosis by increasing cleaved caspase-3[1].
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