產品屬性：
產品名稱 | sPLA2 Inhibitor |
規(guī)格 | 500μg、1mg、5mg、10mg |
貨號 | EY-01Y17088 |
Cas No.: 393569-31-8
別名: N/A
化學名: N/A
分子式: C31H37NO4
分子量: 487.6
溶解度: DMF: 5 mg/ml,DMSO: 2 mg/ml,Ethanol: 5 mg/ml,Ethanol:PBS (pH 7.2) (1:6): 0.1 mg/ml
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
Secreted phospholipases A2 (sPLA2s) are a diverse family of low molecular weight PLA2s with tissue-specific expression patterns and actions. The group IIA sPLA2 (sPLA2-IIA) was originally purified from platelets and exudates from patients with rheumatoid arthritis. Its expression can be induced by inflammatory mediators, and mouse studies suggest that it may play roles in colorectal polyposis, atherosclerosis, and bacterial infections. sPLA2 inhibitor is an orally active inhibitor of sPLA2-IIA. It protects against intestinal reperfusion injury in rats when given at 10 mg/kg orally. sPLA2 inhibitor also attenuates NF-κB signaling in lung cancer cells and protects against diet-induced metabolic syndrome in rats.
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