產(chǎn)品屬性：
產(chǎn)品名稱(chēng) | hSMG-1 inhibitor 11e |
規(guī)格 | 10mM*1 mL in DMSO、5 mg、10 mg |
貨號(hào) | EY-01Y13060 |
Cas No.: 1402452-10-1
別名: N/A
化學(xué)名: N/A
分子式: C26H27N7O3S
分子量: 517.6
溶解度: DMSO : 50 mg/mL (96.60 mM; Need ultrasonic)
儲(chǔ)存條件: 4°C, away from moisture and light
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產(chǎn)品描述：
hSMG-1 inhibitor 11e is a potent and selective hSMG-1 kinase inhibitor with an IC50 of 900-fold selectivity over mTOR (IC50 of 45 nM), PI3Kα/γ (IC50s of 61 nM and 92 nM) and CDK1/CDK2 (IC50s of 32 μM and 7.1 μM)[1].hSMG-1 kinase plays a dual role in a highly conserved RNA surveillance pathway termed nonsense-mediated RNA decay (NMD) and in cellular genotoxic stress response. Since deregulation of cellular responses to stress contributes to tumor growth and resistance to chemotherapy, hSMG-1 is a potential target for cancer treatment[1].[1]. Ariamala Gopalsamy, et al. Identification of pyrimidine derivatives as hSMG-1 inhibitors. Bioorg Med Chem Lett. 2012 Nov 1;22(21):6636-41.
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