產(chǎn)品屬性：
產(chǎn)品名稱 | Angiotensin II 5-valine |
規(guī)格 | 10mM*1mL in Water5mg、50mg、100mg |
貨號 | EY-01Y12141 |
Cas No.: 58-49-1
別名: N/A
化學名: N/A
分子式: C49H69N13O12
分子量: 1032.15
溶解度: H2O : ≥ 257.5 mg/mL (249.48 mM)
儲存條件: -20°C, protect from light
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產(chǎn)品描述：
Angiotensin II 5-valine is an agonist of angiotensin receptor. Angiotensin receptor[1].By day 12, systolic blood pressure (SBP) increases significantly in Angiotensin II 5-valine infused rats (197±7 mm Hg). As shown, the development of hypertension in ANG II infused rats is prevented by losartan treatment. Blood and kidney samples are harvested, subjected to HPLC to separate Angiotensin II 5-valine (exogenous) from Ile5-ANG II (endogenous) and the fractions are measured by radioimmunoassay. In the Angiotensin II 5-valine infused rats treated with losartan, total plasma ANG II levels are elevated to a greater extent than in rats not treated with losartan (289±20 v 119±14 fmol/mL). However, losartan markedly decrease by 88% the enhancement of intrarenal Val5-ANG II content that occurred in the rats infused with Val5-ANG II alone[1].
[1]. Zou LX et al. Renal uptake of circulating angiotensin II in Val5-angiotensin II infused rats is mediated by AT1 receptor. Am J Hypertens. 1998 May;11(5):570-8.
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