產(chǎn)品屬性：
產(chǎn)品名稱 | Rofecoxib-d5 |
規(guī)格 | 500μg、1mg |
貨號 | EY-01Y10876 |
Cas No.: 544684-93-7
別名: N/A
化學(xué)名: N/A
分子式: C17H9D5O4S
分子量: 319.4
溶解度: Acetonitrile: soluble,DMSO: soluble
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產(chǎn)品描述：
Rofecoxib-d5 is intended for use as an internal standard for the quantification of rofecoxib by GC- or LC-MS. Rofecoxib is a non-steroidal anti-inflammatory drug (NSAID) that selectively inhibits COX-2 over COX-1 with IC50 values of 0.018 and >15 μM, respectively, for production of prostaglandin E2 in CHO cells expressing the recombinant human enzymes.1 In vivo, rofecoxib inhibits carrageenan-induced paw edema and hyperalgesia (ID50s = 1.5 and 1.0 mg/kg, respectively), LPS-induced pyresis (ID50 = 0.24 mg/kg), and M. butyricum-induced arthritis (ID50 = 0.74 mg/kg per day) in rats. Formulations containing rofecoxib were previously used in the treatment of pain and arthritis.
特別提醒公司產(chǎn)品僅供科研使用
