產(chǎn)品屬性：
產(chǎn)品名稱 | Satratoxin H |
規(guī)格 | 500μg、1mg、5mg |
貨號 | EY-01Y10661 |
Cas No.: 53126-64-0
別名: N/A
化學名: N/A
分子式: C29H36O9
分子量: 528.6
溶解度: Dichloromethane: soluble,DMSO: soluble,Ethanol: soluble
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產(chǎn)品描述：
Satratoxin H is a trichothecene mycotoxin that has been found in Stachybotrys.1 It induces production of reactive oxygen species (ROS), increases in malondialdehyde (MDA) levels, and induces apoptosis in PC12 cells when used at concentrations ranging from 5 to 100 nM. Satratoxin H is cytotoxic to human umbilical vein endothelial cells (HUVECs; IC50 = 6.8 ng/ml), as well as HepG2, A549, A204, U937, and Jurkat cancer cells (IC50s = 1.2-3.4 ng/ml).2 In vivo, satratoxin H induces ulceration of the small intestine in, and is lethal to mice (LD50 = 5.69 mg/kg).3|1. Nusuetrong, P., Pengsuparp, T., Meksuriyen, D., et al. Satratoxin H generates reactive oxygen species and lipid peroxides in PC12 cells. Biol. Pharm. Bull. 31(6), 1115-1120 (2008).|2. Nielsen, C., Casteel, M., Didier, A., et al. Trichothecene-induced cytotoxicity on human cell lines. Mycotoxin Res. 25(2), 77-84 (2009).|3. Yoshizawa, T., Ohtsubo, K., Sasaki, T., et al. Acute toxicities of satratoxins G and H in mice--a histopathological observation with special reference to the liver injury caused by satratoxin G. Proc. Jpn. Assoc. Mycotoxicol. 23, 53-57 (1986).
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